カイノイドの合成

概要

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Recent syntheses of kainoids were reviewed with 96 references. In the syntheses, formation of the proline nucleus and stereochemical arrangement of the substituents around the proline ring were the key steps, in which ene-reactions, homo- and hetero-Diels-Alder reactions, radical ring closures, Claisen rearrangement and 1, 3-dipolar cyclo-additions were mainly employed. A new method for a pyridine synthesis was also developed for acromelic acids. The synthetic schemes were classified into the following 5 groups according to the position of C-C bond formation in the key steps. 1) C3-C4 bond formation, 2) C2-C3 and C4-C5 bond formation, 3) side chain introduction to proline moiety, 4) conversion of kainic acid to other kainoids and 5) some other synthetic approaches and syntheses of derivatives.
社団法人有機合成化学協会の論文