チョウセンサザエの有毒成分-1-イオウを有する有毒アミン2成分の単離〔英文〕

概要

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From the viscera of a marine snail, Turbo argyrostoina, two acetone-soluble toxins were newly obtained besides the previously known toxins. These new toxins were purified by acidic alumina and by silicic acid column chromatography. The main component, tentatively named toxin A, was eluted from the silicic acid column with chloroform-methanol (1:1) and the minor one, named toxin B, with methanol. Each toxin was purified by subsequent paper or thin-layer chromatography and gel-filtration. Both toxins were soluble in dilute acids, methanol, ethanol, and aqueous acetone, and insoluble in chloroform and diethyl ether. They showed no absorption maxima in the UV region and possessed tertiary or quaternary nitrogen and sulfur functions in the molecules. Symptoms in mice caused by i.p. injection of these new toxins were distinctly different from those induced by the previously found water-soluble and diethyl ether-soluble toxins, consisting of strong paralysis in limbs and death from respiratory failure within 20min.