Effects of polyunsaturated fatty acids and/or lecithin on the plasma concentrations of very low density lipoprotein-tryglyceride(VLDL) and ketone bodies in humans.

概要

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The purpose of this study was to determine the effects of oral intake of linoleic acid (LA) with eicosapentaenoic acid (EPA), and/or lecithin (LC) on the plasma concentraions of ketone bodies and very low density lipoprotein-tryglyceride (VLDL-TG) in 9 healthy males. Four test lipids containing LA as a basic material were ingested in this study; in test-A, only LA was given; in test-B, LA and LC were given ; in test-C, LA and EPA were given ; and in test-D, LA, EPA and LC were given. All subjects received the 4 tests at 5 day intervals. Plasma levels of ketone bodies and VLDL-TG were elevated during test A. Plasma concentrations of acetoacetic acid (ACAC) and beta hydroxybutyrate (3HOB) were significantly elevated during test C, whereas those in test B were not elevated. Plasma VLDL-TG levels in test B and C changed in the opposite manner to the ketone body levels. However, both plasma ketone bodies and VLDL-TG levels were not significantly elevated in test-D, which contained LC and EPA in addition to LA. These results suggest that human ketogenesis and lipogenesis may be accelerated by polyunsaturated fatty acids, or LA with LC, respectively. The study demonstrates that the acceleration of ketogenesis and lipogenesis can be reduced by the combination of LA, EPA and LC, suggesting a potentially recommendable diet for diabetics who are prone to atherosclerosis.
久留米大学医学部 The Kurume Medical Journal 編集部の論文