Construction of DNA-Au nanoparticles multilayer and its application to detection of DNA hybridization
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概要
- 論文の詳細を見る
We have developed a sensitive detection system for DNA hybridization containing DNA-Au nanoparticles (DNA-GPs) multilayer which leads to the enhancement of the detection sensitivity of surface plasmon resonance (SPR) signals. The SPR angular shift, which is the difference in the SPR angles before and after hybridization, becomes amplified with increasing number of layers of the DNA-GPs. A similar increase in SPR angular shift was obtained for the target DNA with low concentration. The reason for the enhancement is attributed to the interaction between Au nanoparticles and the Au film, as well as the increase in immobilized probe DNA content on the substrate.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2004-05-15
著者
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Hayashida Masayuki
Core Research For Evolution Science & Technology (crest) Japan Science & Technology Corporat
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Liu Hongchun
Department Of Ecosystem Engineering Graduate School Of Engineering The University Of Tokushima
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Matsuo S
Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'
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Yamaguchi Akira
Department Of Biology Faculty Of Science Hirosaki University
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Misawa Hiroaki
Core Research for Evolution Science & Technology (CREST), Japan Science & Technology Corporation (JST), Japan
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Misawa H
Core Research for Evolution Science & Technology (CREST), Japan Science & Technology Corporation (JST), Japan
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Yamaguchi Akira
Department of Chemistry, Graduate School of Science, The University of Tohoku, Aoba-ku, Sendai 980-8578, Japan
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Liu Hongchun
Department of Ecosystem Engineering, Graduate School of Engineering, The University of Tokushima, 2-1 Minamijosanjima, Tokushima 770-8506, Japan
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