Ground-glass inclusions in hepatocellular carcinoma.

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Hepatocellular carcinoma (HCC) with ground-glass inclusions was light and electron microscopically and immunohistochemically studied.<BR>HCC With ground-glass inclusions was found in 3 of 127 consecutive autopsy cases of HCC and its frequency Was 2.3%. Clinically, repeated episodes of hypoglycemic attack was noted in one of the 3 cases.Light microscopically, the inclusions were pale and amorphous, and were negative on PAS, PTAH, and orcein stains.Electron microscopically, the inclusions Were seen as well-demarcated, membrane-bound fine fibrillar materials.Varying degrees of dilatation of endoplasmic reticulum containing a similar materials as the inclusion were also observed. Most of the inclusions were found to be positive to anti-fibrinogen by immunoperoxidase method. Thus, it is predicted that ground-glass inclusions in HCC may be intracytoplasmic accumulation of fibrinogen due to defected intracytoplasmic transport of secreted fibrinogen in cancer cells.
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