癌を内包する肝過形成結節の病理形態学的研究.-外科切除例を中心に-

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Pathomorphologic features were studied on 10 resected cases of hyperplastic nodules of the liver. All the 10 nodules were found in cirrhotic liver. The containment of well-differentiated minute cancerous foci was recognized in 5 of the 10 nodules. Regardless of the presence of the cancerous foci, all hyperplastic nodules were not much different grossly and microscopically. The mean (±SD) size of the nodules with and without cancerous foci was 16.2±4.9 and 9.4±4.9mm, respectively and the former being significantly larger than the latter (p<0.02).<BR>Varying degrees of fatty change of the nodules were seen in 4 (80%) of the 5 hyperplastic nodules containing cancerous foci and in all the 3 small hepatocellular carcinomas (HCCs) containing noncancerous liver cell cords in part. Thus, it was suggested that the presence of varying degree of fatty change in those nodules might be closely related to the deveropmental process of HCC from the hyperplastic nodules. Furthermore, it was predicted that there might be a certain trasnsitional process between the hyperplastic nodules with fatty change and small HCC containing non-cancerous liver cell cords. Thus, it is necessary to do meticulous follow-up study on the hyperplastic nodules, particularly those with fatty change.
社団法人日本肝臓学会の論文