The protective effect of inducer on galactosamine hepatitis.

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We examined the effect of inducers on galactosamine (gal) hepatitis in rat. We first induced S.D. male rat by polychlorinated biphenyl (PCB), phenobarbital (PB) and 3-methylcholanthrene (3MC), respectively, and administerd single intraperitoneal injection of gal, then periodically observed the change of drug metabolizing activity.<BR>In gal only administered rat, the content of cytochrome P-450 decreased to 34.7% of control three days after, but PCB, PB, 3MC induced group, decrement of activity was suppressed, minimal value were 96.3%, 89.1%, 63.8% of control, respectively. The content of cytochrome b5 and the activity of NADPH-cytochrome c reductase showed the same change with P-450. Metabolizing activities of aminopyrine, benzo(a)pyrene, anilin were also protective from gal, and histological study also supports this phenomenon.<BR>We found the protective effect of inducers on gal hepatitis, the intensity of that effect was PCB, PB, 3MC in order.
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