Clinicopathological study on liver injury in young adult patients with measles.

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Eight young adult patient (15-23 yr) were studied. They were the patients who required hospitalization among patients having suffered from measles at the young adult age and visited our hospital in 1988 and thereafter. All of the patients showed a slight elevation of GOT, GPT and LDH but no jaundice. Serum GPT level increased with development of rash, reached maximum 6 to 7 days after their appearance, and then returned gradually to the normal level. Serum LDH increased at the time of appearance of rash, reached maximum 4 to 5 days after their appearance (i.e. 2 to 3 days earlier than the peak of GPT), and returned to normal about 2 weeks after onset of rash. Serum Al-P decreased transiently in 4 of the 8 patients. In the recovery stage, liver biopsy was madein 6 of the 8 patients. Histological examination showed slight necrosis of liver cells in all patients but no significant changes in portal area.
社団法人日本肝臓学会の論文