胆汁酸のリンパ球幼弱化反応に及ぼす抑制効果とその機序について

概要

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The effects of the serum of the patients with intrahepatic cholestasis (IHC), free bile acids and conjugated bile acids on the lymphoproliferative response to mitogens such as PHA, PWM and con A were investigated in vitro. Both of the serum of IHC and total bile acid extracted from IHC inhibited the lymphocyte transformation. Most of conjugated bile acids caused lesser degrees of inhibition than the respective free bile acids, and the inhibition was marked in DCA, CDCA and LCA. At the concentration of 10mol/L, all of bile acids showed inhibitory action, and at higher concentration the response was much suppressed. Glycoconjugated bile acids showed similar effects on the transformation as tauroconjugated bile acids. The ultrastructure of the lymphocytes which showed lesser response revealed that the destruction of cristae of mitochondria was marked, on the other hand the cell menbrane was not impaired. These results led to conclude that bile acids induced suppressin of lymphoproliferative transformation by damaging intracellular organella.
財団法人日本消化器病学会の論文