自己免疫性肝疾患,特に原発性胆汁性肝硬変症と慢性活動性肝炎重複症例に出現する新しいマーカー抗体

概要

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An uncharacterized antibody was found in a patient afflicted with primary biliary cirrhosis or chronic active hepatitis. This antibody (which we tentatively called the MM antibody) could be detected by means of double immunodiffusion using the microsomal fraction of rat liver as the antigen. However, cytoplasmic staining in both rat liver and kidney could not be obtained when viewed by indirect immunofluorescent microscopy. The MM antibody did not react with mitochondrial fraction of rat liver. The antibody showed nonidentity with anti-liver kidney microsome antibodies when tested by means of double immunodiffusion. It was found in 5 of 5 PBC-CAH overlap patients who were diagnosed histopathologically, 3 of 19 PBC patient sera and in 2 of 14 CAH patient sera. However, it was not found in non-autoimmune hepatitis patients, nor in the healthy subjects. In conclusion, the detection of MM antibody might be useful for the diagnosis of autoimmune liver diseases particularly, PBC-CAH overlap patient.
日本臨床免疫学会の論文