Synthesis and Evaluation of Dioleoyl Glyceric Acids Showing Antitrypsin Activity
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概要
- 論文の詳細を見る
Previously, Lešová et al. reported the isolation and identification of metabolite OR-1, showing antitrypsin activity, produced during fermentation by Penicillium funiculosum. The structure of OR-1 was a mixture of glyceric acid (GA), esterified with C14-C18 fatty acids, and oleic acid (C18:1) as the most predominant fatty acid (Folia Microbiol. 46, 21–23, 2001). In this study, dioleoyl D-GA and dioleoyl L-GA were synthesized via diesterification with oleoyl chloride, and their antitrypsin activities were evaluated using both a disk diffusion method and spectral absorption measurements. The results show that both compounds and their equivalent mixtures possess antitrypsin activities; however, their IC50 values (approximately 2 mM) are much higher than that of OR-1 (4.25 μM), suggesting that dioleoyl GA does not play a major role in the OR-1 antitrypsin activity.
- 日本油化学会の論文
著者
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KITAMOTO Dai
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industria
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Fukuoka Tokuma
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industria
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Fukuoka Tokuma
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Science An
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Habe Hiroshi
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industria
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SAKAKI Keiji
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industria
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Kitamoto Dai
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sakaki Keiji
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Habe Hiroshi
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sato Shun
Research Institute for Innovations in Sustainable Chemistry, National Institute of Advanced Industri
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Sato Shun
Research Institute for Innovations in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)
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Sato Shun
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)
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