Synthesis of Dilinoleoyl-D-Glyceric Acid and Evaluation of Its Cytotoxicity to Human Dermal Fibroblast and Endothelial Cells
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概要
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A novel derivative of glyceric acid (GA), dilinoleoyl-D-glyceric acid (LA2-DGA), was synthesized from D-GA calcium salt and linoleoyl chloride and evaluated for cytotoxicity. The D-GA calcium salt was first reacted with 4-methoxybezylchloride, and the resulting compound was esterified with linoleoyl chloride. This reaction was followed by hydrolysis of the 4-methoxybenzyl moiety, yielding LA2-DGA. LA2-DGA was then subjected to cytotoxicity testing using normal human dermal fibroblasts and primary normal human dermal microvascular endothelial cells. LA2-DGA showed no significant toxic effects in either type of cell.
著者
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Fukuoka Tokuma
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Science An
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Kitamoto Dai
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sakaki Keiji
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Habe Hiroshi
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sato Shun
Research Institute for Innovations in Sustainable Chemistry, National Institute of Advanced Industri
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