Stepwise synthesis of 2,3-O-dipalmitoyl-D-glyceric acid and an in vitro evaluation of its cytotoxicity
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概要
- 論文の詳細を見る
2,3-O-Dipalmitoyl-D-glyceric acid (PA2-DGA) was synthesized from D-glyceric acid calcium salt and palmitoyl chloride with improved yield. Direct condensation between the D-glyceric acid calcium salt and palmitoyl chloride produced PA2-DGA with a yield of <10%, whereas stepwise synthesis yielded this compound at up to 24% of overall yield. PA2-DGA was then subjected to a cytotoxic test using normal human dermal fibroblasts and primary normal human dermal microvascular endothelial cells. This compound had no toxic effects on human cells in vitro at concentrations up to 34 μM.
著者
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Fukuoka Tokuma
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Science An
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Kitamoto Dai
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sakaki Keiji
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Habe Hiroshi
Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Industrial
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Sato Shun
Research Institute for Innovations in Sustainable Chemistry, National Institute of Advanced Industri
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Sato Shun
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)
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