鼻腔通気性のない喉摘患者の鼻粘膜表層中の好塩基性細胞

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We have reported that the basophilic cells migrate on the mucosal surface of the nose and play an important role in the nasal manifestation of allergy, and that these surface basophilic cells also increase in patients with non-allergic nasal polyps. These facts suggested us that these cells increase as a consequence of nasal blockage. In order to confirm this suggestion, we counted the number of the cells in nasal scrapings from 14 laryngectomized patients and, as control, from 9 patients with irradiated laryngeal cancer.As the results, the basophilic cells increased in 92% of the laryngectomized patients, while only in 25% of the irradiated patients. In the former patients, however, the increases were marked within 2 years (esp. a few months) after operation, and slight over 2 years.In conclusion, breathing through tracheal opening possibly increases the number of surface basophilic cells, although a further study is necessary to know the reason why tracheostomatal breathing causes the increases of surface basophilic cells.
社団法人日本耳鼻咽喉科学会の論文