頭頸部悪性腫瘍患者の免疫能 : 第4報手術と照射に伴う免疫能の変動

概要

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Before and after two different methods of treatment (operation and radiation), humoral and cellular immunities were examined in patients with head and neck cancer. Variation of immunological reactivity exhibited different patterns between the two groups, even when malignant tumors disappeared. In the operation group, humoral immunities were elevated in terms of the serum levels of α2-globulin, complement (CH50), IgA, IgG and Carcinoembrionic Antigen (CEA). Cellular immunities, however, showed no change. In the irradiation group, humoral immunities were not changed, but cellular immunities were significantly depressed showing decreases in the number of peripheral lymphocytes and in the degree of PHA-induced lymphocyte transformation. The above-mentioned patterns of immunological changes were observed in patients without cancer as well. The elevated humoral immunity in the operation group recovered to the pretreatment level within a few months, whereas the suppressed cellular immunity in the irradiation group was pressumed to persist for a longer time.
社団法人日本耳鼻咽喉科学会の論文