Long term effect of immunotherapy for perennial nasal allergy.

概要

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From 1980 to 1985, 678 patients with nasal allergy were found to have perennial sensitivity to house dust at the ENT clinic of Nippon Medical School. These patients were divided into two groups, one was treated with immunotherapy until May 1987. Questionnair were mailed to all the patients asking about severity of nasal symptoms at the time of the first visit and after Immunotherapy, and whether or not they were being treated with other methods at the present time.Answers were received from 235 patients. Improvement was noted in 40% of the patients after 6 months, in 52% after 7-l2 months, in 61% after 13-24 months, in 64% after 25-36 months, in 81% after 37 months or more of the immunotherapy. Of the 87 patients in the non-immunotherapy group 56% improved, but more of these patients had milder symptoms than did those treated with immunotherapy. There was a statistically significant difference in improvement between the immunotherapy group for more than 37 months and the non-immunotherapy. Treatment with other drugs is still needed in 51% of the patients who did not have immunotherapy, in 40% of those with immunotherapy for less than 6 months, in 39% of those with 7-12 months, in 33% of those with 13-24 months, in 16% of those with 25-36 months, in 18% of those with over 37 months of immunotherapy.
耳鼻咽喉科臨床学会の論文