A Case of Glomerular Lipidosis Accompanied by Familial Combined Hyperlipidemia and Panhypopituitarism.
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概要
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This is a report of a case of glomerular lipidosis with familial combined hyperlipidemia and panhypopituitarism. A 60-yr-old woman was admitted for evaluation of hyponatremia. Administration of hydrocortisone normalized the level of serum Na. A pituitary hormone-stimulating test and brain computed tomography revealed panhypopituitarism with an empty sella. Glucocorticoid deficiency due to secondary hypoaldosteronism was thought to have caused the Na loss. She had been treated for thyroid dysfunction and hyperlipidemia with replacement of thyroid hormone and a lipid-lowering drug. Hyperlipidemia changed from type V into IIa in 4 yr. Furthermore, one of her brothers and one of her sons were suspected to have type IV hyperlipidemia. Familial combined hyperlipidemia accompanied by secondary hypothyroidism was thought to have increased the levels of both total cholesterol and triglyceride. Two renal biopsies in 3 yr showed lipid deposits in the mesangial cells and indicated a positive correlation between the levels of serum lipids and lipid deposits in glomeruli, which suggested an important role of abnormal lipid metabolism in the progression of glomerular lipidosis.(Internal Medicine 31 : 44-49, 1992)
著者
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Fukazawa Yuichiro
Department Of Pathology Kkr Sapporo Medical Center
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Suzuki Akihiko
Department Of Brewing And Fermentation Tokyo University Of Agriculture
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Yamamoto Hiroshi
Departmemt Of Chemical Engineering University Of Tokyo
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ABE Tomoko
Department of Medicine, Iwamizawa Municipal General Hospital
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Abe Tomoko
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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KONDO Takahito
The First Department of Medicine, School of Medicine, Hokkaido University
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KAWAKAMI Yoshikazu
The First and the Third Department of Medicine, Hokkaido University
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WATANABE Naoyoshi
Department of Medicine, Iwamizawa Municipal General Hospital
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KURODA Rensuke
Department of Medicine, Iwamizawa Municipal General Hospital
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SUZUKI Akihiko
Department of Medicine, Iwamizawa Municipal General Hospital
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