Nervous Control of the Renal Tubular Function

概要

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The role of the renal nerves in renal tubular function-which is still a controversial subject-was studied by observing the changes in renal nerve activity and urine formation before, during and after the left stellate ganglion stimulation. The experiments were performed on 7 dogs anesthetized with a combination of morphine and α-chloralose. The activity of one of the renal nerves was picked up by a platinum bipolar electrode and recorded. During the left stellate ganglion stimulation, the rate of discharge of renal nerve activity decreased in the number of bursts and, at the same time, increases in urine volume and excretion of sodium, potassium and solutes were observed, while the urinary concentrations of sodium, potassium and osmolality decreased. These alterations produced by stellate ganglion stimulation were characterized by a rapid onset and, with cessation of stimulation, a rapid disappearance. There was observed complete recovery after the stimulation. On the other hand, the estimation of glomerular filtration rate revealed no significant changes through each experimental period. The mechanisms of stellate ganglion stimulation diuresis were discussed and it was assumed that there was nervous control operating on renal tubular function, especially in the proximal tubules.
International Heart Journal刊行会の論文