The Quantitative Appraisal of Coronary Vascular Lesion in Experimental Hypertension and Hypercholesterolemia with Special Reference to Intramural Arteriolosclerosis

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概要

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• An attempt was made to investigate experimentally whether arteriolosclerosis in the myocardium was accelerated by concomitant arterial hypertension and/or hypercholesterolemia. Young male albino rabbits were divided into 5 groups, i.e., hypertensive, hypertensive and hypercholesterolemic, normotensive and hypercholesterolemic, operated but normotensive and control group, respectively. Hypertension was induced by means of a modified Goldblatts technique and hypercholesterolemia by feeding lanolin and cotton seed oil. To obtain the media/diameter ratio of small arteries and arterioles in the myocardium, the constricted and deformed vessels were stretched completely and the widths of the media and external diameter of corrected vessels were calculated geometrically. The frequency of the small vessels having the intimal changes was compared in each group. The media/diameter ratios of small arteries and arterioles in the myocardium increased in the groups with hypertension and were not influenced by hypercholesterolemia. The media/diameter ratios in each rabbit declined linearly in 40 to 110μ. of external diameter and did not show a specific increase. Endothelial hyperplasia and splitting and proliferation of the internal elastic lamina were the main intimal changes of the small myocardial arteries and arterioles in the rabbits which were not fed with lanolin and cotton seed oil. These intimal changes were found most frequently in the subendocardial regions of the left ventricles of hypertensive rabbits. It was suggested that the medial changes of arterioles and small arteries in the myocardium were related to hypertension and the intimal changes were accelerated by hypertension but might not he primarily caused by hypertension.

• International Heart Journal刊行会の論文

著者

• Takeuchi Jugoro

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• SAKAI Shuichiro

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• TAKADA Akira

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• NISHIDE Keijiro

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• OHYA Nobuo

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• KITAMURA Kenji

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• TAKEUCHI Jugoro

  First Department of Internal Medicine, Kanazawa University School of Medicine

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