Autoregulation of Renal Circulation

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概要

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• (1) A total of 19 canine kidneys were perfused in situ with the donor's blood or with PVP solution to demonstrate the presence of autoregulation of renal circulation and to investigate the mechanism of it.(2) The rate of renal blood flow was measured at various levels of perfusion pressure. The rate of renal blood flow was increased proportionately less than the rise in perfusion pressure within a range of approximately 70-200mm.Hg both in innervated and denervated kidneys. This pressure-flow regulation was not deteriorated by the infused dibenamine hydrochloride or regitine inactivating catecholamine, but it was completely abolished by the administration of papaverine hydrochloride, a known direct smooth muscle relaxant. Thus, the presence of autoregulation of renal circulation, the mechanism of which being ascribed to the myogenic nature of the renal vasculature, was demonstrated.(3) Transient change in renal blood flow after the sudden release of arterial occlusion was composed of the initial sharp rise followed by the rapid reduction towards the control value. The time interval for this response was within several seconds. The rapid reduction following the initial sharp rise in renal blood flow disappeared during the papaverine administration. These findings provided a further support for the active myogenic process of intrarenal vasculature as a causal factor of autoregulation.(4) During the perfusion with PVP solution, autoregulation was not evident. This is probably due to the damage of renal vasculature by the agent.(5) During the direct infusion of high concentration of norepinephrine, renal blood flow was reduced to subnormal value and autoregulation disappeared. This fact suggests that autoregulation is not a participant of maintaining sufficient renal blood flow in circulatory emergency which being intensely influenced by humoral factors.(6) In some kidneys, the effect of elevated venous pressure on renal circulation was studied. Reduction of arterio-venous pressure difference solely produced by elevation of venous pressure was also accompanied by decrease in resistance. It is therefore suggested that the mechanism of autoregulation is related to the arterio-venous pressure difference rather than to the absolute level of arterial pressure.

• International Heart Journal刊行会の論文

著者

• KITAGAWA Tetsundo

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• KUBO Tadashi

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• TAKEUCHI Jugoro

  First Department of Internal Medicine, Kanazawa University School of Medicine

• NAKADA Yoshio

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• SAWADA Taisei

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• FUNAKI Etsuro

  First Department of Internal Medicine, School of Medicine, Kanazawa University

• SANADA Minoru

  First Department of Internal Medicine, School of Medicine, Kanazawa University

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