Hemodynamic effects of BTB-cyclic AMP in anesthetized dogs.
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概要
- 論文の詳細を見る
The hemodynamic effects of 8-benzylthio-N6-n butyl adenosine 3', 5' cyclic monophosphate (BTB-cAMP) were studied in anesthetized dogs. BTB-cAMP was given intravenously in doses of 1, 3 and 9mg/kg, respectively. BTB-cAMP induced dose-dependent increases in heart rate, max LV dp/dt, cardiac output and stroke volume, and decreases in mean blood pressure and total peripheral resistance. BTB-cAMP had less of an effect on heart rate and blood pressure than dibutyryl cAMP (DB-cAMP), but showed a greater effect in augmenting cardiac contractility, with earlier manifestations of maximum action. Although the duration of its action is shorter, BTB-cAMP has possible therapeutic applications in cardiovascular diseases such as cardiogenic shock and congestive heart failure. It may also be a better agent than DBcAMP for the treatment of patients with congestive heart failure because of a less potent hypotensive effect.
- International Heart Journal刊行会の論文
著者
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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ITO Takayuki
Second Department of Internal Medicine, Nagoya University School of Medicine
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SATAKE Tatsuo
Second Department of Internal Medicine, Nagoya University School of Medicine
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IMURA Kazumasa
Second Department of Internal Medicine, Nagoya University School of Medicine
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