Decreased Generation of Cyclic AMP in Lymphocytes by β-Adrenergic Stimulation in Heart Failure

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概要

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• Peripheral blood lymphocytes from 31 normal subjects and 29 patients with heart diseases were stimulated by isoproterenol, and cyclic AMP level in lymphocytes was assayed. Simultaneously plasma norepinephrine concentration at rest was measured. In normal subjects the generation of cyclic AMP after the stimulation decreased with age. The response of lymphocytes in patients of NYHA classes III and IV was significantly smaller than in the normal, age-matched control. Plasma norepinephrine concentration of patients of classes II, III, and IV rose significantly above normal. In congestive heart failure, a significant correlation between plasma norepinephrine concentration and increase of lymphocyte cyclic AMP was demonstrated. From these results it was suggested that β-adrenergic receptors in congestive heart failure were desensitized

• International Heart Journal刊行会の論文

著者

• Satake Tatsuo

  Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya

• Ogawa Kouichi

  Second Department Of Internal Medicine Nagoy University School Of Medicine

• BAN Masaaki

  Second Department of Internal Medicine Nagoya University, School of Medicine

• Minakuchi Kazue

  Second Department of Internal Medicine Nagoya University School of Medicine

• Minakuchi Kazue

  The 2nd Dep. Of Internal Medicine Nagoya University School Of Medicine

• MINAKUCHI Kazue

  Second Department of Internal Medicine, Nagoya University School of Medicine

• SATAKE Tatsuo

  Second Department of Internal Medicine, Nagoya University School of Medicine

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