PATTERN OF DISTRIBUTION OF DOPAMINE-β-HYDROXYLASE ACTIVITY IN NORMAL SUBJECTS AND IN PATIENTS WITH MITRAL STENOSIS OR LEFT TO RIGHT SHUNTS
スポンサーリンク
概要
- 論文の詳細を見る
Eighteen patients with mitral stenosis and twelve patients with left-to-right shunts heart disease and six normal subjects were catheterized and plasma dopamine-β-hydroxylase (DBH) activities in various parts of cardiovascular system were measured in order to assess the role of sympathetic activity in pulmonary hypertension. Arteriovenous differences of DBH activities were positive in normal subjects and patients with normal pulmonary artery pressure. A negative difference was found in patients with pulmonary hypertension. DBH activity in patients with pulmonary hypertension was significantly elevated compared with that of normal subjects. There was a weak correlation between mean pulmonary artery pressure and DBH activity in pulmonary artery. There were significant differences between normal, mitral stenosis with pulmonary hypertension and left-to-right shunts heart diseases about the pattern of distribution of DBH activity among these groups. A significant difference of the distribution between mitral stenosis with normal pulmonary artery pressure and that with pulmonary hypertension was also found. These findings suggested that a prolonged, increased level of sympathetic nervous system activity among patients with mitral stenosis and left-to-right shunt heart disease developed pulmonary hypertension. Thus, a significant contribution of sympathetic nervous activity to the establishment of pulmonary hypertension was suggested.
- 社団法人日本循環器学会の論文
- 1979-03-20
著者
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Mizutani Koya
The Third Department Of Internal Medicine Aichi Medical University
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ITO TAKAYUKI
Second Devision, Department of Internal Medicine, Faculty of Medicine, Nagoya University
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Ogawa Kouichi
Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya
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Satake Tatsuo
Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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Mizutani Keiji
Meijo Hosp
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SHIOZU Hatsutoshi
Second Department of Internal Medicine Nagoya University, School of Medicine
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MIZUTANI KEIJI
Meiji Hospital
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Ban Masaaki
The 2nd Department Of Internal Medicine Nagoya University School Of Medicine
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Mizutani Keiji
Meijo Hosptital
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Mizutani Kohya
The Third Department Of Internal Medicine Aichi Medical University
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BAN MASA-AKI
Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya and Department
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Ito Takayuki
Second Devision Department Of Internal Medicine Faculty Of Medicine Nagoya University
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Mizutani Keiji
Cardiovas. Clinic Meijo Hospital
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Shiozu Hatsutoshi
Second Department Of Internal Medicine Nagoya University School Of Medicine Nagoya And Department Of
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Ban Masayuki
The 2nd Dept. Of Intern. Med. Nagoya Univ. School Of Med.
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Mizutani Koya
Meiji Hospital
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Mizutani Keiji
Ii Division Department Of Internal Medicine Nagoya University
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Ban Masa-aki
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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Shiozu Hatsutoshi
The 2nd Dep. Of Internal Medicine Nagoya University School Of Medicine
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Ban Masa-aki
Second Department Of Internal Medicine Nagoya University School Of Medicine Nagoya And Department Of
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ITO Takayuki
Second Department of Internal Medicine, Nagoya University School of Medicine
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SATAKE Tatsuo
Second Department of Internal Medicine, Nagoya University School of Medicine
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