Effects of Dibutyryl Cyclic AMP on Patients with Severe Heart Failure

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概要

• 論文の詳細を見る

• Dibutyryl cyclic AMP was administered to 2 patients with severe congestive heart failure. After an intravenous drip infusion of dibutyryl cyclic AMP (300mg/40min), marked diuresis and mild improvement of the patients physical activity occurred. The cardiac index increased and both systemic vascular resistance and pulmonary capillary wedge pressure decreased. Blood glucose and plasma insulin increased simultaneously, while plasma free fatty acid decreased during the infusion. A continuous intravenous micro-infusion of dibutyryl cyclic AMP (300mg/24h) also exerted diuresis and improved physical activity. The hemodynamic and metabolic effects of dibutyryl cyclic AMP are expected to be beneficial to a failing heart.

• International Heart Journal刊行会の論文

著者

• Hashimoto Hidekazu

  Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya

• Okumura Kenji

  Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya

• Ogawa Kouichi

  Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya

• Ogawa Kouichi

  Second Department Of Internal Medicine Nagoy University School Of Medicine

• Hashimoto H

  名古屋大学 第2内科

• NIIZOE Ken-ichi

  Second Department of Internal Medicine, Nagoya University School of Medicine

• OGAWA Kouichi

  Second Department of Internal Medicine, Nagoya University School of Medicine

• OKUMURA Kenji

  Second Department of Internal Medicine, Nagoya University School of Medicine

• HASHIMOTO Hidekazu

  Second Department of Internal Medicine, Nagoya University School of Medicine

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