The Effects of Dilazep and SG 75 on Cyclic Nucleotides in the Coronary Artery
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概要
- 論文の詳細を見る
We examined the effects of new long acting coronary vasodilators (dilazep and SG 75) on cyclic nucleotides in the coronary artery and the myocardium at the maximum coronary blood flow. The cyclic AMP concentrations in the anterior descending coronary artery after the injection of saline (control), SG 75 (0.2mg/Kg), and dilazep (0.1mg/Kg) were 229±20pmole/Gm, 249±21pmole/Gm, and 320±21 pmol/Gm, respectively. A significant increase above control values was found in the dilazep treated group (p<0.02). The cyclic GMP concentrations in the coronary artery after the injection of saline, SG 75, and dilazep were 35.6±4.4pmole/Gm, 40.4±3.3pmole/Gm, 35.3±3.2pmole/Gm, respectively. There were no significant differences between them. The cyclic AMP and cyclic GMP concentrations in the left ventricular muscle did not significantly increase after the administration of dilazep and SG 75. Our findings showed that the mechanism of coronary vasodilating action of dilazep might be associated with an increased cyclic AMP in the coronary artery.
- International Heart Journal刊行会の論文
著者
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KOBAYASHI Akira
Second Department of Surgery, Faculty of Medicine, Kagoshima University
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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YAMAZAKI Noboru
Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya University
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Kobayashi Akira
Second Department Of Surgery Faculty Of Medicine Kagoshima University
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YAMAZAKI Noboru
Second Department of Internal Medicine, Nagoya University School of Medicine
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KOBAYASHI Akira
Second Department of Internal Medicine, Nagoya University School of Medicine
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