EFFECTS OF EXCESSIVE NORADRENALINE ON CARDIAC MITOCHONDRIAL CALCIUM TRANSPORT AND OXIDATIVE PHOSPHORYLATION
スポンサーリンク
概要
- 論文の詳細を見る
Mitochondrial oxidative phosphorylation, calcium transport activity and calcium content were investigated in dog hears injured by excessive noradrenaline (NA). Diffuse cardiac injury was produced by a 5-hour infusion of NA (2 or 5 μg/kg/min), and the injury was evaluated based on ECG and hemo-dynamic changes. Mitochondrial calcium uptake and binding activities measured in the presence of ATP showed no significant differences between the control and NA groups. However, the calcium content of hear mitochondria isolated from the NA groups, state 3 respiration and the respiratory control index were significantly depressed without any change in the ADP/O ratio. These results suggest that excessive NA causes the intracellular calcium overload and the depression of mitochondrial respiration, and the both of these changes may play a key role in the pathogenesis of myocardial injury through the insufficient control of cytosolic calcium levels.
- 社団法人日本循環器学会の論文
- 1984-05-20
著者
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Ogawa Kouichi
Meijo Hospital
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Ogawa Kouichi
Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya
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Satake Tatsuo
Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya
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Miyazaki Yutaka
2nd Dept.of Internal Medicine Nagoya University School Of Medicine
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Miyazaki Yutaka
名古屋大学 生化
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Satake T
Departments Of Internal Medicine Faculty Of Medicine University Of Nagoya
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Sone Takahito
Second Department Of Internal Medicine Faculty Of Medicine University Of Nagoya
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Ogawa K
Meijo Hospital
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MIYAZAKI YUTAKA
Second Department of Internal Medicine, Faculty of Medicine, University of Nagoya
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Shibata T
Nagoya Univ. Nagoya Jpn
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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Miyazaki Yutaka
The 2nd Department Of Internal Medicine Nagoya University School Of Medicine
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Satake Tatsuo
The 2nd Dept. Of Internal Medicine Nagoya University School Of Medicine
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SATAKE Tatsuo
Second Department of Internal Medicine, Nagoya University School of Medicine
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