Concentration of Myocardial Cyclic AMP and Ventricular Fibrillation Induced by Aminophylline
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概要
- 論文の詳細を見る
The concentration of myocardial cyclic AMP was measured in 9 dogs by radioimmunoassay after the administration of aminophylline. Fourteen dogs served as control. The concentration of cyclic AMP in the left ventricle was the highest and the lowest value was obtained in the right atrium in the control dogs. Ventricular fibrillations were induced immediately after the injection of 30mg/Kg aminophylline in 3 dogs out of 9. The concentration of the left ventricular cyclic AMP in 6 dogs which tolerated aminophylline was significantly elevated compared with that of the control dogs (p<0.05). The left ventricular cyclic AMP in 3 dogs with ventricular fibrillation was significantly higher compared with that in the aminophylline tolerated dogs with non-fibrillating hearts (p<0.01).These results showed that the concentration of cyclic AMP was elevated in the fibrillating heart.
- International Heart Journal刊行会の論文
著者
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Ogawa Kouichi
Second Department of Internal Medicine, Nagoya university School of Medicine, Nagoya
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SUGIURA MASAHIKO
Second Department of Surgery, Nagoya City University Medical School
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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Sugiura Masahiko
Second Department Of Surgery Nagoya City University Medical School
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YAMAZAKI Noboru
Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya University
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