CHANGES OF PLASMA 6-Keto-PGF_<1α> AND THROMBOXANE B_2 LEVELS AND PLATELET AGGREGATION AFTER TOURNIQUET ISCHEMIA ON THE UPPER LIMB IN NORMAL SUBJECTS AND PATIENTS WITH ISCHEMIC HEART DISEASE
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the pathophysiology of ischemic heart disease (IHD), tourniquet ischemia on the upper limb was done and changes in platelet aggregation, plasma 6-keto-PGF_1α concentrations and plasma thromboxane B_2 (TXB_2) concentrations were studied. At rest, platelet aggregability and plasma TXB_2 concentrations were significantly increased in IHD patients compared with those in normal subjects (p<0.001 and p<0.001, respectively). In normal subjects, platelet aggregability, plasma 6-keto-PGF_1α concentrations and plasma TXB_2 concentrations rose significantly during ischemia (p<0.05, p<0.02 and p<0.05, respectively). In addition, plasma 6-keto-PGF_1α concentrations were significantly lower in IHD patients than in normal subjects during ischemia (p<0.005), though there was no significant change in the level of either group at rest. These results suggest that increase in prostacyclin synthesis in normal subjects during tourniquet ischemia may be a defense mechanism to maintain the balance between prostacyclin and thromboxane A_2 (TXA_2) and to prevent platelet aggregation induced by the procedure. Increase in platelet aggregation and TXA_2 generation in IHD patients at rest indicates a close correlation between IHD and platelet reactivity. Tourniquet ischemia induced a significant increase in prostacyclin generation in normal subjects but not in IHD patients, which suggests that production of prostacyclin was impaired in IHD patients during ischemia. A marked difference was obvious in prostacyclin and TXA_2 generation between IHD patients and normal subjects, and this difference may play an important role in the pathogenesis of IHD.
- 社団法人日本循環器学会の論文
- 1982-07-20
著者
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Ogawa Kouichi
Meijo Hospital
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Satake Tatsuo
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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Ito Takayuki
The Second Department of Internal Medicine, Nagoya University School of Medicine
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OGAWA KOUICHI
The Second Department of Internal Medicine, Nagoya University School of Medicine
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Long Shlung
The 2nd Dept. Of Internal Medicine Nagoya University School Of Medicine
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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LONG SHlUNG
The Second Department of Internal Medicine, Nagoya University School of Medicine
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Long Shiung
The 2nd Dept. Of Internal Medicine Nagoya University School Of Medicine
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Ito Takayuki
Departments Of Internal Medicine
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Ogawa Kouichi
The Second Department Of Internal Medicine Nagoya University School Of Medicine
-
Chen Long
The Second Department of Internal Medicine, Nagoya University School of Medicine
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