Myocardial Norepinephrine and Cyclic AMP Concentration following Myocardial Ischemia : Relation to Ventricular Fibrillation and Sudden Death : The Nature of Sudden Death and Its Prevention
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to investigate the relationships of myocardial concentrations of norepinephrine (NE) and cyclic AMP (c-AMP) to the development of ventricular fibrillation (VF) with reference to the effects of a premedication of dibutyryl cyclic AMP (DBC-AMP) and propranolol in dogs with experimental myocardial infarction. Myocardial specimens were obtained serially from the ischemic and the non-ischemic zones by mini-drill biopsy, and NE and c-AMP levels were determined by high-performance liquid chromatography and radioimmunoassay, respectively. Before the occurrence of VF, myocardial NE increased in both the ischemic and the non-ischemic zones, and c-AMP increased significantly in the ischemic zone but did not in the non-ischemic zone. In dogs premedicated with DBC-AMP an increase of c-AMP was observed in both the ischemic and the non-ischemic zone in association with an increased incidence of VF. On the other hand, no significant increase of myocardial c-AMP was observed in both the ischemic and the non-ischemic zones of propranolol-premedicated dogs which were free from VF. A significant increase of myocardial c-AMP in the ischemic zone was observed in dogs which suffered from VF in spite of the premedication of propranolol. The incidence of VF was significantly reduced by 26.5% in dogs pretreated with propranolol. No significant changes in myocardial norepinephrine and c-AMP were observed in dogs which were free from VF throughout the experiments.
- 社団法人日本循環器学会の論文
- 1983-05-20
著者
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OGAWA KOUICHI
The Second Department of Internal Medicine, Nagoya University School of Medicine
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BAN MASAAKI
The Second Department of Internal Medicine, Nagoya University School of Medicine
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Ogawa Kouichi
Second Department Of Internal Medicine Nagoy University School Of Medicine
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Kanayama Hitoshi
The 2nd Department of Internal Medicine Nagoya University School of Medicine
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Ban Masaaki
The 2nd Department Of Internal Medicine Nagoya University School Of Medicine
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Ukai Masatoshi
The Second Depertment Of Internal Medicine Nagoya University School Of Medicine
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Ukai Masatoshi
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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KANAYAMA HITOSHI
The Second Depertment of Internal Medicine, Nagoya University School of Medicine
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Ukai Masatoshi
The 2nd Dep. Of Internal Medicine Nagoya University School Of Medicine
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Kanayama Hitoshi
Dept Of Internal Med Kamo Hosp.
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Ban Masayuki
The 2nd Dept. Of Intern. Med. Nagoya Univ. School Of Med.
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Ban Masa-aki
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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Ogawa Kouichi
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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Ban Masaaki
The Second Department Of Internal Medicine Nagoya University School Of Medicine
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