Prognostic Effects of Combined Treatment With Calcium Channel Blockers and Statins in Patients With Coronary Narrowing : From the Japanese Coronary Artery Disease Study
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概要
- 論文の詳細を見る
Calcium channel blockers (CCB) and statins are frequently prescribed for patients with coronary artery disease (CAD) complicated by hypertension and/or hypercholesterolemia. CCB have pleiotropic actions beyond their blood pressure-lowering effect, while statins have pleiotropic actions beyond their cholesterol-lowering effect. We assessed the hypothesis that combined treatment with CCB and statins has additional prognostic benefits resulting from potential additive or synergistic pleiotropic actions of both classes of drugs in the Japanese CAD (JCAD) study population. The JCAD study consisted of 13,812 patients with angiographically demonstrable significant coronary narrowing in at least 1 of 3 major coronary arteries who were followed-up for a mean of 2.7 years (follow-up rate, 88.4%). The primary endpoint of the present study was all cardiovascular events. We compared the event rate between patients receiving neither CCB nor statins and those receiving each drug alone or as a combination treatment using propensity score matching analysis. The rate of all events was 62.8 per 1,000 patient-years in the JCAD study. Kaplan-Meier analysis with the log-rank test showed no statistically significant difference in the event rate in each comparison. In conclusion, there may be no additional prognostic benefit beyond the blood-pressure-lowering and cholesterol-lowering effects in the combined treatment with CCB and statins for angiographically documented CAD patients.
著者
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Yamazaki Tsutomu
Department Of Applied Chemistry Graduate School Of Engineering Tokyo University Of Agriculture And T
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Fujita Masatoshi
Human Health Sciences Graduate School Of Medicine Kyoto Univ.
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Sasayama Shigetake
Faculty Of Life And Medical Science Doshisha University
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YAMAZAKI Tsutomu
Department of Clinical Epidemiology & Systems, Graduate School of Medicine, The University of Tokyo
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Hayashi Dobun
Translational Research for Health Care and Clinical Science, Graduate School of Medicine, The University of Tokyo
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Kohro Takahide
Translational Research for Health Care and Clinical Science, Graduate School of Medicine, The University of Tokyo
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Mitani Satoko
Human Health Sciences, Kyoto University Graduate School of Medicine
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Okada Yoshihiro
Translational Research for Health Care and Clinical Science, Graduate School of Medicine, The University of Tokyo
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