Pure Red Cell Aplasia Associated with Imatinib-Treated FIP1L1-PDGFRA Positive Chronic Eosinophilic Leukemia
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概要
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A 28-year-old man with marked eosinophilia is described. FIP1L1/PDGFRA mRNA showed multiple alternatively-spliced fusion transcripts. Sequencing analysis showed that the deduced DNA breakpoints were intron 10 in the FIP1L1 gene and exon 12 in the PDGFRA gene. Then, a diagnosis of chronic eosinophilic leukemia (CEL) was made. Whereas the response to the treatments with prednisolone and hydroxyurea were unsatisfactory, treatment with imatinib showed a rapid decrease of eosinophils. The hemoglobin level also dropped and bone marrow examination showed pure red cell aplasia. Continued administration of very low dose imatinib (100 mg every 5 days) led to and maintained complete molecular remission, with good tolerability.
著者
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Tanaka Hideo
Department of Pathology and Cell Regulation,Kyoto Prefectural University of Medicine
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Iwato Koji
Department of Blood Transfusion, Hiroshima Red Cross and Atomic Bomb Survivors Hospital
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Asou Hiroya
Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima U
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Kimura Akiro
Department of Hematology & Oncology, Research Institute for Radiation Biology and Medicine, Hiroshim
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Iwato Koji
Department Of Blood Transfusion Hiroshima Red Cross Hospital And Atomic-bomb Survivors Hospital
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Kimura Akiro
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Tanaka Hideo
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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ASOU Hiroya
Department of Cancer Cytogenetics, Research Institutefor Nuclear Medicine and Biology
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Asou Hiroya
Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
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