Goods Syndrome-Associated Pure Red Cell Aplasia with Myelodysplastic Syndrome

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概要

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• We report a case of Goods syndrome-associated pure red cell aplasia (PRCA) with myelodysplastic syndrome (MDS). In this case, effector memory T (TEM) cells were expanded in the bone marrow. It remains uncertain whether the development of MDS was caused by the basic marrow defects or radiation therapy. However, since CD8+ perforin+ TEM cells expanded in the bone marrow, as was previously described for 3 of our patients with thymoma-associated PRCA, it is highly possible that the pathogenic mechanism of PRCA that is accompanied by thymoma is related to the expanded CD8+ perforin+ TEM cells in this MDS-complicated case.

著者

• Kimura Akiro

  Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi

• Nitta Hideaki

  Department Of Synthetic Chemistry The University Of Tokyo

• Harada Yuka

  International Radiation Information Center Research Institute For Radiation Biology And Medicine Hir

• Harada Hironori

  Department Of Agricultural Chemistry The University Of Tokyo

• Okikawa Yoshiko

  Department Of Hematology And Oncology Division Of Clinical Research Research Institute For Radiation

• Arihiro Koji

  Department Anatomical Pathology Hiroshima University Hospital

• Fujii Masayoshi

  Department Of Anatomical Pathology Hiroshima University Hospital

• Harada Yuka

  International Radiation Information Center, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan

• Okikawa Yoshiko

  Department of National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan

• Kimura Akiro

  Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan

• Arihiro Koji

  Department of Anatomical Pathology, Hiroshima University, Japan

• Harada Hironori

  Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan

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