Spatiotemporal Visualization of Intracellular Ca^<2+> in Living Heart Muscle Cells Viewed by Confocal Laser Scanning Microscopy
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概要
- 論文の詳細を見る
Ca^<2+> ions play pivotal roles in the excitation and contraction-relaxation processes of heart muscle cells. The advent of digital-imaging techniques, especially confocal laser scanning microscopy, as well as Ca^<2+>-sensitive fluorescent dyes, has contributed substantially to the precise understanding of the spatiotemporal aspects of the intracellular Ca^<2+> dynamics in cardiomyocytes. In this review article, we review the progress in the cytochemical and histochemical researches on the intracellular Ca^<2+> concentration ([Ca^<2+>]_i) of the heart. Recent imaging technologies have revealed that subcellular [Ca^<2+>]_i dynamics are spatiotemporally heterogeneous under certain pathological conditions. We focus on the Ca^<2+> waves, i.e., representative of abnormal [Ca^<2+>]_i dynamics that emerge under [Ca^<2+>]_i-overloaded conditions, analyzed in preparations ranging from the enzymatically isolated myocytes to the whole heart. The pathophysiological significance of Ca^<2+> waves in the heart is also discussed.
- 日本組織細胞化学会の論文
著者
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Tanaka Hideo
Department of Pathology and Cell Regulation,Kyoto Prefectural University of Medicine
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TAKAMATSU Tetsuro
Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Takamatsu Tetsuro
Department Of Pathology And Cell Regulation Kyoto Prerectural University Of Medicine
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Takamatsu T
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Takamatsu T
Department Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine
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Takamatsu Tetsuro
Department Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine
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Takamatsu Tetsuro
Department Of Pathology And Cell Regulation And Department Of Urology Kyoto Prefectural University O
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Tanaka Hideo
Department Of Hygiene And Preventive Medicine Fukushima Medical University
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Tanaka Hideo
京都府立医科大学 細胞分子機能病理学
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Tanaka Hideo
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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