Toward an Integrated Understanding of the Purkinje Fibers in the Heart : The Functional and Morphological Interconnection between the Purkinje Fibers and Ventricular Muscle
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概要
- 論文の詳細を見る
Purkinje fibers are an essential element of the conduction system that provides for coordinated ventricular contraction of the heart. Although classic studies established structure and electrical activities of Purkinje fibers, an integrated understanding of the Purkinje-ventricular interconnection within the working heart remains to be had. In this review article we will briefly overview the gross anatomy and cytological characteristics of Purkinje fibers and their transition to the ventricular muscle, and we will discuss functional and morphological aspects of the Purkinje-ventricular interconnection from the perspectives of electrophysiology, distribution of gap junctions, and intracellular Ca^<2+> ([Ca^<2+>]_i) dynamics. Furthermore, the potential usefulness of the recently developed optical voltagemapping and in situ real-time confocal [Ca^<2+>]_i imaging techniques is discussed as an integrated approach to the pathophysiological investigation of the Purkinje-ventricular interconnection in the heart.
- 日本組織細胞化学会の論文
著者
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Tanaka Hideo
Department of Pathology and Cell Regulation,Kyoto Prefectural University of Medicine
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TAKAMATSU Tetsuro
Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Hamamoto Tetsu
Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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Takamatsu T
Department Of Pathology And Cell Regulation Kyoto Prefectural Univesity Of Medicine
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Hamamoto Tetsu
Department Of Pathology And Cell Regulation Kyoto Prefectural University Of Medicine:department Of C
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Hamamoto Tetsu
京都府立医科大学 細胞分子機能病理学
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Takamatsu Tetsuro
Department Of Pathology And Cell Regulation And Department Of Urology Kyoto Prefectural University O
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Tanaka Hideo
Department Of Pathology And Cell Regulation Kyoto Prefectural Univesity Of Medicine
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Tanaka Hideo
Department Of Hygiene And Preventive Medicine Fukushima Medical University
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Tanaka Hideo
Department Of Hematology And Oncology
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Tanaka Hideo
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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