Class III .BETA.-Tubulin Expression in Tumor Cells is Correlated with Resistance to Docetaxel in Patients with Completely Resected Non-Small-Cell Lung Cancer
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概要
- 論文の詳細を見る
Objective To assess the relationship between in vitro chemosensitivity evaluated by the histoculture drug response assay (HDRA) and the expression of β-tubulin isotypes in tumors of patients with completely resected NSCLC in order to determine the predictive value of β-tubulin in chemotherapy for NSCLC. Methods Expression of β-tubulin isotypes was immunohistochemically analyzed in a series of 58 tumor samples from patients with completely resected NSCLC. The sensitivity of individual tumors to anticancer agents was evaluated by HDRA. Results Class III β-tubulin expression by tumor cells was significantly correlated with resistance to docetaxel (p=0.0250), but not related with resistance to gemcitabine. Patient characteristics (age, gender, histology, and stage) were not associated with class III β-tubulin expression. Conclusion An abundance of class III β-tubulin in tumor cells could be a biomarker for resistance to docetaxel in patients with completely resected NSCLC.
- 社団法人 日本内科学会の論文
著者
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Kagamu Hiroshi
Division Of Respiratory Medicine Department Of Homeostatic Regulation And Development Course In Biol
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KURIYAMA Hideyuki
Division of Clinical Nephrology and Rheumatology
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Yoshimasu Tatsuya
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University
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Umezu Hajime
Division Of Cellular And Molecular Pathology
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Gejyo Fumitake
Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical
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Umezu Hajime
Division of Surgical Pathology, Niigata University Medical and Dental Hospital
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Hayashi Yoshiki
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Tanaka Junta
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital
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Furukawa Tomoko
SRL, Inc.
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Tanaka Hiroshi
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital
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Yoshizawa Hirohisa
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital
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Kuriyama Hideyuki
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Kagamu Hiroshi
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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