In Vitro Evaluation of the Effect of Cardiac Surgery on Cancer Cell Proliferation
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概要
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Objective: Operative stress of cardiovascular surgery can alter the blood levels of various physiologically active substances (e.g., cytokines, growth factors), and thus potentially affect cancer cell proliferation. How the combination of changes in blood levels of these substances affects cancer cells has not been adequately addressed. We investigated the stimulatory capacity on cancer cells of serum from patients after cardiovascular surgery, using a novel in vitro assay method.Methods: The subjects were 22 patients undergoing cardiovascular surgery, consisting of 11 off-pump and 11 on-pump procedures. Blood was sampled from each subject immediately before surgery, immediately after surgery, and after transfer to the intensive care unit. Human lung cancer cells were exposed to the serum of each blood sample from each patient, and an MTT assay was conducted to evaluate cell proliferation.Results: Serum samples of all patients showed an inhibitory effect for lung cancer cell proliferation. This inhibitory effect was lower in postoperative serum compared with serum samples before surgery. As a result, lung cancer cell proliferation was better with postoperative serum samples than preoperative serum samples. The proliferation rate after surgery, when it was compared with preoperative serum, was significantly higher in patients with on-pump procedures than in patients with off-pump procedures.Conclusion: The results of this study suggest that the operative stress of cardiovascular surgery induces changes in serum to make it less inhibitory for the cancer cell proliferation. This phenomenon is greater in patients with extracorporeal circulation.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
- 2011-06-01
著者
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Nishimura Yoshiharu
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine
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Uchida Shunji
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University School Of Medicine
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Nishimura Yoshiharu
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University School Of Medicine
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Nishimura Yoshiharu
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical College
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Okamura Yoshitaka
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University School Of Medicine
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Okamura Yoshitaka
Department Of Cardiovascular Surgery Wakayama Medical University
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Yoshimasu Tatsuya
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University
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Yoshimasu Tatsuya
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University
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Yamamoto Shuji
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University School Of Medicine
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Uchita Shunji
Department Of Cardiovascular Surgery And Pediatric Cardiology Seirei Hamamatsu General Hospital
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Honda Kentaro
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University School Of Medicine
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Yamamoto Shuji
Department Of Hematology And Oncology University Of Fukui
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TOGUCHI Koji
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University
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Honda Kentaro
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University
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Toguchi Koji
Department Of Thoracic And Cardiovascular Surgery Wakayama Medical University
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Yamamoto Shuji
Department of Applied Chemistry, Yamanashi University
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