Invasive Pulmonary Aspergillosis with Hematological Malignancy Caused by Aspergillus terreus and in vitro Susceptibility of A. terreus Isolate to Micafungin
スポンサーリンク
概要
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A 35-year-old man developed invasive pulmonary aspergillosis (IPA) with severe neutropenia after umbilical cord stem cell transplantation for chronic myelogeneous leukemia. Filamentous fungus isolated from his sputum was identified as Aspergillus terreus. Despite systemic amphotericin B (AMPH) administration, IPA progressed. However, intravenous administration of micafungin (MCFG) and oral itraconazole improved clinical data and symptoms, although he later died of massive hemoptysis. Examination of the in vitro susceptibility of this A. terreus isolate to MCFG revealed a good minimum inhibitory concentration and good time-kill assay results compared to AMPH. Thus, MCFG might be useful for IPA caused by A. terreus.
著者
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Saikawa Tetsunori
Laboratory and Diagnostic Medicine, Faculty of Medicine, Oita University
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Kadota Jun-ichi
Department Of Internal Medicine Faculty Of Medicine Oita University
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Tokimatsu Issei
Department Of Infectious Diseases Oita University Faculty Of Medicine
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Ishii Hiroshi
Department Of Chemical Science And Engineering Tokyo National College Of Technology
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Ogata Masao
Department Of Basic Science Graduate School Of Arts And Science University Of Tokyo
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Kishi Kenji
Department of Respiratory Medicine (Internal Medicine II), Oita University Hospital
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Kushima Hisako
Department of Infectious Diseases, Oita University Faculty of Medicine
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Hashinaga Kazuhiko
Department of Infectious Diseases, Oita University Faculty of Medicine
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Iwata Atsuko
Department of Infectious Diseases, Oita University Faculty of Medicine
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Umeki Kenji
Department of Infectious Diseases, Oita University Faculty of Medicine
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Ohama Minoru
Department of Infectious Diseases, Oita University Faculty of Medicine
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Kohno Kazuhiro
Department of Infectious Diseases, Oita University Faculty of Medicine
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Hiramatsu Kazufumi
Department of Infectious Diseases, Oita University Faculty of Medicine
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Kishi Kenji
Department of Infectious Diseases, Oita University Faculty of Medicine
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Kadota Jun-ichi
Department of Internal Medicine 2, Oita University Faculty of Medicine, Japan
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Kohno Kazuhiro
Department of Hematology, Oita University Faculty of Medicine
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Kadota Jun-ichi
Department of Infectious Diseases, Oita University Faculty of Medicine
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