Manipulation of Major Membrane Lipid Synthesis and Its Effects on Sporulation in Saccharomyces cerevisiae
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概要
- 論文の詳細を見る
During the sporulation process of Saccharomyces cerevisiae, meiotic progression is accompanied by de novo formation of the prospore membrane inside the cell. However, it remains to be determined whether certain species of lipids are required for spore formation in yeast. In this study, we analyzed the requirement of the synthesis of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and ergosterol for spore formation using strains in which the synthesis of these lipids can be controlled. When synthesis of PE and PC was repressed, sporulation efficiency decreased. This suggests that synthesis of these phospholipids is vital to proper sporulation. In addition, sporulation was also impaired in cells with a lowered sterol content, raising the possibility that sterol content is also important for spore formation.
著者
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Ohta Akinori
Department of Agricultural Chemistry, The University of Tokyo
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Ono Yusuke
Department Of Medicine And Science In Sports And Exercise Tohoku University Graduate School Of Medic
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Fukuda Ryouichi
Department of Biotechnology, The University of Tokyo
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Deng Lan
Department of Biotechnology, The University of Tokyo
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Nagasawa Jumpei
Department of Biotechnology, The University of Tokyo
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ISHIKAWA Yasuhisa
Department of Biotechnology, The University of Tokyo
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KAKIHARA Toru
Department of Biotechnology, The University of Tokyo
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