Mechanism of Action of Tetrocarcin A
スポンサーリンク
概要
- 論文の詳細を見る
Tetrocarcin A strongly inhibited incorporation of 14C-uracil and 14C-D-glucosamine into B. subtilis in vivo. It had no effect on PM2 DNA in vitro. It caused 50% inhibition of DNA dependent RNA polymerase from E. coli at a concentration of about 0.1mM, while B. subtilis RNA polymerase was inhibited only 20-30% at a concentration of 0.08 μm and the degree of inhibition did not increase at a higher concentration. The fact that inhibition of RNA synthesis was abolished in permeabilized cells of B. subtilis and leakage of cellular constituents was caused by tetrocarcin Asuggests that RNA synthesis is not the primary target and cell membrane is affected by tetrocarcin A in B. subtilis.
- 社団法人 日本農芸化学会の論文
著者
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TAMAOKI Tatsuya
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd
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Kawamura Fujio
Institue Of Applied Microbiology The University Of Tokyo
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Saito Hiuga
Institute Of Applied Microbiology University Of Tokyo
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TOMITA Fusao
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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TOMITA Fusao
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd.
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TAMAOKI Tatsuya
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd.
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