Biosynthesis and Production of Tetrocarcin A, a New Antitumor Antibiotic in Chemically Defined Medium

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概要

• 論文の詳細を見る

• A chemically defined medium was devised to examine the growth, production and biochemical pathway of tetrocarcin A. The production of tetrocarcin A was greatly stimulated by L-leucine and its corresponding keto acid, α-ketoisocaproate, suggesting that L-leucine is involved in the biosynthesis of tetrocarcin A. About 10-12 μg/ml of tetrocarcin A was produced in a chemically defined medium consisting of 20g sucrose, 2.5g KNO3, 5g MgSO4•7H2O, 5g KH2PO4 and 1g L-leucine per liter of water (pH 7.0).

• 社団法人 日本農芸化学会の論文

著者

• TAMAOKI Tatsuya

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd

• TOMITA Fusao

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.

• TAMAOKI Tatsuya

  Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.

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• Inhibition of Lymphocyte Kinase Lck and Phosphatidylinositol 3-kinase by a Novel Immunosuppressant, Lymphostin(Biochemistry & Molecular Biology)
• Biosynthesis and Production of Tetrocarcin A, a New Antitumor Antibiotic in Chemically Defined Medium
• Mechanism of Action of Tetrocarcin A

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