Enantioselective amination of silylketene acetals with (N-arylsulfonylimino)phenyliodinanes catalyzed by chiral dirhodium(II) carboxylates: asymmetric synthesis of phenylglycine derivatives
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概要
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The first catalytic enantioselective amination of silylketene acetals with (N-arylsulfonylimino) phenyliodinanes is described. The reaction of silylketene acetals derived from methyl phenylacetates with [N-(2-nitrophenylsulfonyl)imino] phenyliodinane (NsN = IPh) under the catalysis of dirhodium(II) tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate], Rh_{2}(S-TCPTTL)_{4}, proceeds in benzene at room temperature to give N-(2-nitrophenylsulfonyl) phenylglycine derivatives in high yields and with enantioselectivities of up to 99% ee.
- Elsevierの論文
- 2007-12-10
著者
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橋本 俊一
北大院薬
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TANAKA Masahiko
NIMS Beamline Station at Spring-8, National Institute for Materials Science
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Tanaka Masahiko
Nims Beamline Station At Spring-8 National Institute For Materials Science
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Tanaka Masahiko
National Institute For Materials Science
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Hashimoto Shunichi
Faculty Of Pharmaceutical Sciences Hokkaido University
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Anada Masahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University
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