ドナー・アフェレシスの最先端/血小板採取時の白血球除去(<特集>21世紀のアフェレシス-作用機序と臨床効果のエビデンス)

概要

論文の詳細を見る
Contaminating leukocytes in blood products are thought to be one cause of transfusion-associated side effects. Leukocyte-derived cytokines, leukocyte fragments, released cytoplasmic substances, and soluble leukocyte antigens are candidate substances to cause side effects. Leukocyte reduction during apheresis or before storage will be effective to prevent them, and several measures have been introduced into the apheresis systems. Nonhemolytic side effects, however, still occur in spite of these strategies, suggesting that platelet-derived chemokines or plasma proteins are causing these events in some cases. To overcome severe side effects in a patient who had experienced hypotensive reactions, we have transfused washed platelets with success in prevention. Further analyses are still needed to elucidate the mechanisms of transfusion- associated side effects.
日本アフェレシス学会の論文
2001-02-28