劇症肝炎治療とアフェレシスの役割(<特集>21世紀のアフェレシス-作用機序と臨床効果のエビデンス)

概要

論文の詳細を見る
Although the term fulminant hepatic failure(FHF), which represents a group of symptoms or a syndrome of failure of liver functions during the course of any type of acute liver injury is popular in Western countries, the term fulminant hepatitis(FH),which represents acute hepatitis and is severe enough to show the symptoms of FHF, is popular in Japan. The logical treatment of FHF is symptomatic treatments. Because of failure in the development of a reliable artificial liver support(ALS),liver transplantation, the final symptomatic treatment, is regarded as the only reliable method of treatment of FHF in Western countries. In Asian countries, where viral FH forms more than 90% of the causes of FHF, treatments aiming at the resolution of severe viral hepatitis should be started immediately after the diagnosis has been made. We have shown that a rapid resolution of severe viral hepatitis is attained by combined antiviral and immunosuppressive treatments. ALS is a basis of such treatments for hepatitis. Our method of ALS, plasma exchange(PE)in combination with hemodiafiltration(HDF),has been recognized as being quite satisfactory for that purpose by leading hospitals in Japan.
日本アフェレシス学会の論文
2001-02-28