Citrus属基原生薬の交感神経作動性物質について
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概要
- 論文の詳細を見る
Hot aqueous extracts of about 150 Chinese crude drugs were submitted to in vitro bioassay using isolated animal organs. Those Chinese drugs derived from Citrus plants remarkably inhibited the rat uterine contraction induced by serotonin. The effective principle having this anti-contraction activity in Auranti Fructus Immaturus (Japanese name "Kijitsu") was found to be synephrine. Synepherine was first prepared as a synthetic Sympathomimetic drug, and later was isolated from the leaves and juice of tangerine. Synephrine was also isolated from "Chinppi"(陳皮), "Kikoku"(枳殻) and "Seihi"(青皮), all of these crude drugs exhibiting the same activity. Quantitative analysis of synephrine was carried out by TLC densitometric analysis to show that the synephrine content of these drugs was 1.3-2.6%.
- 日本生薬学会の論文
- 1979-09-20
著者
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三川 潮
東京大学薬学部
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木下 武司
Faculty Of Pharmaceutical Sciences Teikyo University
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木下 武司
東京大学薬学部
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鮫島 美枝子
東京大学薬学部
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