サンショウウオ胚網膜と水晶体の発生段階に伴う,fibroblast growth factor, transforming growth factor-betaの局在変化

概要

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The localization of acidic fibroblast growth factor (a-FGF), basic fibroblast growth factor (b-FGF) and transforming growth factor-beta (TGF-β) in the retina and lens in the stages of normal embryonic development was immunohistochemically investigated in the Japanese salamander. a-FGF was localized in the neural retina at an early stage but was limited to the posterior pole at a later stage. After the laminar structure had formed, the localization of a-FGF became intense in the photoreceptors. TGF-β was strongly positive in the posterior portion of the neural retina and in the photoreceptors. a-FGF and TGF-β tended to be localized on the anterior side of the lens during lens fiber differentiation. After the nucleus of the lens had formed, the nucleus was stained heavily. b-FGF was localized in the nucleus at the stage of nucleus formation. The results of this study suggested that the growth factors play a role in the induction of morphological differentiation.
東京女子医科大学の論文
1997-10-25