糖尿病患者の血液が水和塩化銅の結晶成長に与える影響

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Dendrites of hydrated cupric chloride crystallized from dihydrated cupric chloride aqueous solutions to which a slight amount of lysed blood from 6 diabetic patients, and 6 healthy persons as controls, was added in vitro, were grown in uncovered Petri dishes (100 mm diameter) under conditions of 28℃ and 45% relative humidity. Multiple nucleation developed from pure cupric chloride solutions, however, addition of 0.5 vol% blood strongly inhibited nucleation. As a result, radial growth of dendrites formed from an average count of about 1.5 initial growth points (0) per dish was achieved by adding blood. Crystal forms in the shape of convex lens consisting of two dendrite arches near the center of the crystal growth point were observed. Their specific crystal growth forms were divided into three categories according to the longer diameter of the convex lens shape: small (S) < 8 mm, median (M) ≧ 8 mm but < 20 mm, large (L) ≧ 20. S growth forms correlated with serum concentration of blood were generated by the blood of both healthy persons and diabetic patients, whereas M and L forms were specific to diabetic patients according to the results of testing by Student's t-test, because the number of M forms per twelve dishes was 14.2±1.4 when diabetic patients blood was used, versus 2.50±0.63 in the control group, and because the number of L forms was 6.50±0.67 and 0.33±0.13 with diabetic patients' blood and healthy persons' blood respectively. The occurrence of these M and L forms was correlated to the concentrations of HbA_1, HbA_<1C>, glucose, creatinine, uric acid, platelets, and ceruloplasmin. The above findings show that blood has an inhibitory effect on nucleation of hydrated cupric chloride crystals and that larger convex lens bodies were formed in the presence of hemolyste of diabetic patients rather than normal controls.
東京女子医科大学の論文
1998-07-25

糖尿病患者の血液が水和塩化銅の結晶成長に与える影響

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