ブドウ球菌スーパー抗原TSST-1の長時間暴露によるウサギ毒素性ショック症候群の誘導とその病態の解析

概要

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A Staphylococcal infectious disease, toxic shock syndrome (TSS), is characterized by acute and systemic disorders, such as fever, erythema, shock, and multi-organ failures. A causative exotoxin of TSS, TSS toxin-1 (TSST-1), one of the bacterial superantigens, activates a vast number of human T cells in Vβ2-selective way and induces overproduction of cytokines. However, it does not exhibit direct cytotoxic actions. Cytokines produced in an excessive amount are primarily involved in the pathogenicity of TSS. In the present study, we analyse abnormal reactions seen in TSS in rabbits induced by long-term exposure to TSST-1 filled in an osmotic pump implanted. All of the rabbits exposed to TSST-1 exhibited acute and systemic abnormal reactions and 60% of them died within 14 days. The rabbits which survived TSS exhibited transient decrease in body weight, erythrocyte counts, and concentration of hemoglobin in peripheral blood, and transient increases in serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase, triglyceride, and total cholesterol values. By comparison, the rabbits that died exhibited steady decreases in body weight, erythrocyte counts, and concentration of hemoglobin in peripheral blood prior to their deaths, and transient increases, in higher degrees than did survived ones, of the other clinical data described above.
東京女子医科大学の論文
1999-10-25