ヒト末梢血のCD4^+T細胞とCD8^+T細胞における細菌性スーパー抗原に対する反応性の相違

概要

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Toxic shock syndrome (TSS) toxin-1 (TSST-1), one of the bacterial superantigens, activates a vast number of Vβ^2+ T cells, which is the major TSST-1-reactive human T-cell fraction. TSST-1 causes TSS and neonatal TSS-like exanthematous disease (NTED). It was found that the activation of Vβ^2+ T cells by TSST-1 was induced in both CD4^+ and CD8^+ T-cell subsets in NTED patients. In the present study we examined TSST-1-induced responses of adult peripheral blood CD4^+ and CD8^+ T cells in vitro. The primary proliferative response and IL-2 production were higher in CD4^+ T cells than in CD8^+ T cells, while IFN-γ production was higher in CD8^+ T cells than in CD4^+ T cells. In the secondary response, T-cell blasts obtained by stimulating CD4^+ T cells with TSST-1 proliferated and produced IL-2 and IL-4 in an accelerated manner upon restimulation with TSST-1. On the contrary, the above responses were negligible in CD8^+ T-cell blasts prepared likewise. IFN-γ production and cytotoxic activity on MHC class II^+ cells were higher in the CD8^+ subset than in the CD^4+ subset. These data indicate that CD4^+ and CD8^+ T cells are activated by bacterial superantigens in specific ways and have different roles in the pathogenesis of diseases.
東京女子医科大学の論文
2001-08-25