病理診断アトラス(12) : 内分泌腫瘍1:下垂体・甲状腺・副甲状腺

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Endocrine tumors are examined from the viewpoints of tumor pathology and functional pathology. Adequate sampling of the tumor and nonneoplastic part is essential for a histological examination. Immunohisto-chemistry, in situ hybridization and FISH, and electron microscopy, in addition to hematoxylin and eosin morphology, are useful tools for pathological diagnosis. This article first describes functioning and nonfunctioning pituitary tumors with immunohistochemistry. Thyroid carcinomas exhibit a full variety of clinical and pathological characteristics according to histological types, including papillary, follicular, poorly differentiated, undifferentiated carcinomas, and medullary carcinoma. The former four are follicular epithelial in origin and the latter is derived from C cells. Histological subtypes of papillary carcinoma have been well correlated with the abnormality of genes. A follicular variant of papillary carcinoma may have some diagnostic problems, among pathologists, with regard to its differentiation from follicular adenoma and adenomatous goiter. Parathyroid adenoma, carcinoma and primary hyperplasia sometimes require differential diagnosis. The present article is to be followed by "Pathology of endocrine tumors, part 2" which will deal with adrenocortical tumors causing primary aldosteronism, Cushing's syndrome and adrenogenital syndrome, and nonfunctioning tumors, adrenomedullary tumors, some tumors of the diffuse neuroendocrine system, ectopic hormone-producing tumors, and multiple/familial neoplastic syndromes.
東京女子医科大学の論文

病理診断アトラス(12) : 内分泌腫瘍1:下垂体・甲状腺・副甲状腺

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