遺伝子組換えトウモロコシ(T-25)のラットを用いた13週間反復投与毒性試験

概要

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The potential subchronic toxicity of a genetically modified corn (T-25, Aventis CropScience) was investigated in F344 rats (10 rats/group both sexes). Rats were given diet containing T-25 at dietary levels of O(control), 2.8, 8.2 or 24.5%. The proportions of corn in the modified NIH open formula of a rat diet, NIH07, were designed to be composed of T-25 and non-gene modified corn at the 4 levels, the total being 24.5%. No treatment-related effects were noted regarding clinical findings, body weights, food and water consumption, hematology, clinical chemistry, ophthalmologic findings and histopathology. In conclusion, 13 weeks dietary treatment with T-25 at levels up to 24.5% demonstrated no lexicologically significant effects in either male or female rats. It was thus inferred that the no-observed adverse effect level (NOAEL) is 24.5% in both sexes.
日本食品化学学会の論文
2003-12-12